Your DNA already determines how you respond to medications

Pharmacogenomic testing analyzes specific genes that affect how your body processes medications. Variations in these genes can influence whether a drug works well for you, requires a dose adjustment, or may cause adverse effects. DecodeMyBio extracts pharmacogenomic variants from your existing consumer DNA data and maps them to clinical guidelines published by CPIC and DPWG.

You upload your raw DNA data file from 23andMe, AncestryDNA, MyHeritage, FamilyTreeDNA, or a VCF file from whole-genome sequencing. Our pipeline extracts clinically relevant genetic variants, maps them to star alleles using PharmVar definitions, determines your metabolizer phenotypes, and cross-references the results against CPIC and DPWG drug-gene interaction guidelines. The result is a Medication Safety Report covering genes like CYP2C19, CYP2D6, and CYP2C9.

DecodeMyBio supports raw data files from 23andMe, AncestryDNA, MyHeritage, FamilyTreeDNA, and VCF files (.vcf or .vcf.gz) from whole-genome sequencing services like Nebula Genomics, Dante Labs, and clinical genetics labs. Each source uses a different format, but all include the genotype data needed for pharmacogenomic analysis. Note: some repeat-based variants (e.g. UGT1A1 *28) may not be representable in standard VCF files.

No — and that is intentional. DecodeMyBio provides informational pharmacogenomic reports, not diagnoses or prescriptions. Our reports are designed to support clinical conversations, not replace them. Every Medication Safety Report includes a Clinician Pocket Summary — a one-page reference your doctor or pharmacist can use alongside your medical history, current medications, and clinical judgment. Always consult your healthcare provider before making any medication changes.

Our analysis uses CPIC (Clinical Pharmacogenetics Implementation Consortium) guidelines — the same evidence-based drug–gene guidelines referenced by hospitals and pharmacies for pharmacogenomic prescribing decisions. We include only findings backed by CPIC Level A (strong) or Level B (moderate) evidence, and every result links to its published source. Each finding also includes a confidence indicator based on your data coverage. However, consumer genotyping arrays test a subset of known variants — some rare alleles may not be detectable, and structural variants (like CYP2D6 gene deletions) cannot be reliably identified from array data. For situations requiring clinical-grade certainty, discuss CLIA-certified pharmacogenomic testing with your healthcare provider.

Your raw DNA file is processed server-side to extract pharmacogenomic variants and is auto-deleted within 30 days of upload. We store only the extracted variant data and your generated report, encrypted at rest and in transit. We do not sell, share, or use your genetic data for research or advertising. You can request complete deletion of your data at any time.

Anyone taking or considering medications metabolized by pharmacogenes may benefit. This is particularly relevant if you take medications like clopidogrel, warfarin, SSRIs (antidepressants), statins, codeine, or certain chemotherapy drugs. It can also be useful if you have experienced unexpected side effects or lack of efficacy with a medication.

Your report includes a dedicated Clinician Pocket Summary — a single page with your gene results, metabolizer phenotypes, affected medications, and suggested clinical actions in a format providers are accustomed to reading. Download the PDF and bring it to your next appointment, or send it through your provider's patient portal. The Clinician Summary gives them everything they need to interpret your results in context, without reading the full report.

Consumer pharmacogenomic analysis has several limitations: not all pharmacogenes or alleles are covered, structural variants may be missed, results don't account for phenoconversion (when other drugs alter your metabolism), and allele databases may underrepresent certain populations. Drug response also depends on non-genetic factors like age, organ function, and diet. See our Limitations page for full details.

Different tools answer different questions. Polygenic risk scores estimate statistical probabilities across hundreds of conditions using thousands of weakly associated variants. Our reports focus on a smaller set of genes with strong, established clinical evidence — the kind of evidence that hospitals and pharmacies already use to adjust prescriptions. Every gene in our analysis has peer-reviewed CPIC guideline support at Level A or B. We analyze fewer genes because we only include genes where the science is strong enough to inform a clinical conversation with your doctor. The result is a report your prescriber can act on — not a probability chart.

Uploading your DNA data and receiving free trait insights is completely free. DecodeMyBio offers six premium reports: the Celiac & Gluten Screening ($19), the Cannabis & CBD Report ($29), the Nutrition & Methylation Report ($39), the Pain & Anesthesia Report ($39), the Medication Safety Report ($49), and the Psychiatric Medication Report ($59). Each is a one-time purchase — because your DNA doesn't change, every report stays relevant across future prescriptions, ER visits, and provider changes. For comparison, clinical pharmacogenomic testing through a hospital typically costs $250–$2,000+. DecodeMyBio uses the same CPIC evidence guidelines at a fraction of the cost, using the DNA data you already have.