Sample · Decode+
See your pain & anesthesia results in Decode+
A real preview of how your genetic variants affect pain medications and anesthesia response — personalized to your genetics.
Free to start · $59 one-time, lifetime access
What you'll see inside Decode+
Decode+ covers 5 genes across pain sensitivity, opioid response, and medication metabolism.
Summary Snapshot
A quick overview of how many actionable scenarios were identified, genes analyzed, and what to do next.
What We See in Your Data
A plain-language synthesis connecting your genetic variants to real-world pain and anesthesia implications.
Scenario Cards
Each scenario explains a specific clinical situation — what it means, which genes are involved, and what to discuss with your provider.
Medications Table
Pain and anesthesia medications mapped to your genetic results with action flags and clinical reasoning.
Limitations & Disclaimers
Transparent disclosure of what your results can and cannot tell you, including gene coverage and evidence level.
Your pain & anesthesia results — full sample
Sample Data — Not Your Results
Your Pain & Anesthesia Results
Inside Decode+ — sample preview
Based on pharmacogenomic research for pain management and anesthesia
Summary Snapshot
Multiple Actionable FindingsYour genetics suggest several important considerations for pain management and anesthesia. Multiple variants affect how you process pain signals and metabolize common pain medications.
Do this next: Share your results with your pain specialist or anesthesiologist before any procedure or new pain medication.
What We See in Your Data
Your CYP2D6 result (*1/*4) means you carry one non-functional allele, placing you in the poor metabolizer category. Codeine and tramadol rely on CYP2D6 to convert into their active forms — for you, these medications are unlikely to provide adequate pain relief at standard doses. Your OPRM1 variant (A/G at rs1799971) is associated with reduced opioid receptor binding, which may mean standard opioid doses provide less analgesic effect. Combined with your COMT result (Met/Met at rs4680), which is linked to lower pain thresholds and higher pain sensitivity, your overall pain management profile suggests a need for careful medication selection and dose adjustment. Your BDNF variant (Val/Met) and ANKK1 variant further contribute to how you experience and recover from pain.
Your Scenarios
Codeine and tramadol require CYP2D6 activation — your enzyme activity is too low for adequate conversion.
Genes Involved
CYP2D6 *1/*4 — Poor Metabolizer
CYP2D6 converts codeine to morphine and tramadol to its active metabolite O-desmethyltramadol. As a poor metabolizer, you produce significantly less of these active compounds. Clinical studies show poor metabolizers achieve less than 10% of the analgesic effect compared to normal metabolizers. This is not a matter of dose adjustment — these medications are fundamentally ineffective for your genotype.
Recommendations
- Codeine and tramadol should generally be avoided — they will not convert to their active forms effectively.
- Alternative analgesics that do not depend on CYP2D6 (such as morphine, oxymorphone, or non-opioid options) may be more appropriate.
- Discuss this finding with your prescriber before any procedure where codeine or tramadol might be prescribed.
- If you have previously found codeine ineffective, this result explains why.
References: CPIC Codeine Guideline 2020, PMID:24458010, PMID:31562822
Your opioid receptor variant is associated with reduced binding affinity and lower analgesic response.
Full scenario with genes involved, explanation, and recommendations in Decode+
Your COMT variant is associated with lower enzyme activity and heightened pain sensitivity.
Full scenario with genes involved, explanation, and recommendations in Decode+
A BDNF variant contributes to differences in how pain signals are transmitted and modulated.
Full scenario with genes involved, explanation, and recommendations in Decode+
An ANKK1/DRD2 variant affects dopamine receptor density, influencing pain recovery and reward processing.
Full scenario with genes involved, explanation, and recommendations in Decode+
4 additional scenarios with full explanations, gene details, and recommendations in Decode+
Pain & Anesthesia Medications
| Medication | Category | Status | Reason |
|---|---|---|---|
| codeine (Tylenol #3) | Opioid Analgesic | Action Required | CYP2D6 Poor Metabolizer — will not convert to active morphine effectively |
| tramadol (Ultram) | Opioid Analgesic | Action Required | CYP2D6 Poor Metabolizer — inadequate conversion to O-desmethyltramadol |
| hydrocodone (Vicodin) | Opioid Analgesic | Action Required | CYP2D6 Poor Metabolizer — reduced conversion to hydromorphone |
| morphine (MS Contin) | Opioid Analgesic | OPRM1 A/G — may require higher doses for adequate analgesia |
| oxycodone (OxyContin) | Opioid Analgesic | OPRM1 A/G — altered receptor binding may reduce efficacy |
+11 more medications checked in Decode+
Limitations & Disclaimers
- Decode+ evaluates CYP2D6, OPRM1, COMT, BDNF, and ANKK1 for pain only. Other genes influencing pain response (e.g., SCN9A, ABCB1, CYP3A4) are not included.
- Genotyping from consumer DNA kits may not capture all star alleles or structural variants. Clinical-grade testing may identify additional variants.
- Pain is multifactorial — genetics is one component alongside psychological, environmental, and contextual factors.
- OPRM1, COMT, BDNF, and ANKK1 findings are based on research-level evidence and are not yet included in CPIC clinical guidelines.
- Medication decisions should always be made with a qualified healthcare provider who can consider your complete clinical picture.
- Decode+ does not account for drug-drug interactions, organ function, or other clinical variables that affect medication response.
This is a sample built from fictional data for demonstration purposes. Your own results in Decode+ reflect your personal genetics.
Decode your own pain & anesthesia response
Upload your 23andMe or AncestryDNA raw data. See your genome overview free; unlock your pain & anesthesia results with a one-time $59 — yours for life.
Get Started FreeFree vs Decode+
Create your account and see your genome overview free. Decode+ maps your variants to specific pain medications and anesthesia considerations.
Free to start
- Create your account & upload 23andMe or AncestryDNA
- Your genome overview — genes analyzed, variants found
- Export or delete your data anytime
- Which pain medications are affected
- Pain sensitivity and opioid response scenarios
- Anesthesia-specific recommendations
Decode+
$59 one-time- Everything in free, plus:
- 5 genes analyzed across pain and anesthesia pathways
- Scenario-based findings with clinical context
- 14 pain medications mapped to your genetic results
- Opioid response and sensitivity profile
- Plus medications, carrier status, nutrition, ancestry & the AI assistant
Pain Pharmacogenomics from DNA You Already Have
Clinical pain PGx testing costs $300+ and requires a new sample, a prescription, and often insurance pre-authorization. Decode+ uses raw data from 23andMe or AncestryDNA — data you already have — free to start, then a one-time $59 you own for life.
Both approaches reference the same pharmacogenomic research for opioid metabolism and pain sensitivity. The difference: you already have the data.
Built on Pharmacogenomic Evidence
CYP2D6 findings reference CPIC clinical guidelines for codeine and tramadol. OPRM1, COMT, BDNF, and ANKK1 findings are based on peer-reviewed pharmacogenomic research with consistent replication across multiple studies.
For educational and informational purposes only. Not a substitute for clinical pharmacogenomic testing or medical advice. See our limitations page for details.
Ready to See Your Pain & Anesthesia Results?
Upload your 23andMe or AncestryDNA raw data and read your results inside Decode+. Free to start — then $59 one-time, yours for life.