Data Sources
DecodeMyBio relies exclusively on established, peer-reviewed pharmacogenomic databases and clinical guideline bodies. We do not use proprietary or unpublished data sources. Below are the primary sources referenced in our analysis pipeline and reports.
CPIC — Clinical Pharmacogenetics Implementation Consortium
CPIC develops peer-reviewed, evidence-based clinical practice guidelines for gene-drug pairs. CPIC guidelines provide specific therapeutic recommendations based on genotype/phenotype, with evidence levels ranging from A (strongest) to D.
DecodeMyBio reports include only CPIC Level A and Level B interactions.
DPWG — Dutch Pharmacogenetics Working Group
The DPWG, part of the Royal Dutch Pharmacists Association (KNMP), publishes pharmacogenomic-based therapeutic dose recommendations. DPWG guidelines complement CPIC guidelines and sometimes cover additional gene-drug pairs or provide alternative dosing recommendations.
PharmVar — Pharmacogene Variation Consortium
PharmVar is the central repository for pharmacogene allele definitions (star allele nomenclature). It provides the variant positions and haplotype definitions used to map genotypes to star alleles for genes including CYP2D6, CYP2C19, CYP2C9, and others.
FDA Table of Pharmacogenomic Biomarkers
The U.S. Food and Drug Administration maintains a table of pharmacogenomic biomarkers in drug labeling. This table identifies drugs whose FDA-approved labels include pharmacogenomic information, providing an additional reference layer for gene-drug associations.
How We Use These Sources
- Allele definitions — PharmVar provides the variant-to-star-allele mappings used in genotype interpretation.
- Clinical guidelines — CPIC and DPWG guidelines determine which drug-gene interactions are reported and what therapeutic context is provided.
- Regulatory reference — The FDA table serves as a cross-reference for drugs with pharmacogenomic labeling.
To understand how these sources feed into your results, read how pharmacogenomic testing works or preview a sample report.
All content on this site follows our published editorial standards.
Last reviewed: February 2025 · DecodeMyBio Editorial Team