Sample · Decode+
See your psychiatric medication results in Decode+
See how CYP2D6 and CYP2C19 results map to antidepressants, ADHD medications, and mood stabilizers. This is a real preview of what you see inside the app — personalized to your genetics.
Free to start · $59 one-time, lifetime access
What you'll see inside Decode+
Decode+ covers CYP2C19 and CYP2D6 with your psychiatric medications mapped by condition.
90-Second Summary
Top impact areas explained in plain language with the medications affected and when this matters.
Condition-Based Grouping
Medications organized by condition — Depression & Anxiety, ADHD, Bipolar — with action levels for each.
Decision Table
A compact reference with every affected medication, your gene result, CPIC level, and suggested consideration.
Detailed Findings
Full gene-by-gene analysis with diplotype, activity score, affected medications, and CPIC evidence level.
Your psychiatric results — full sample
Sample Data — Not Your Results
Your Psychiatric Medications
Inside Decode+ — sample preview
Based on CPIC psychiatric pharmacogenomics guidelines
Your genetics suggest 2 psychiatric medication interactions requiring attention and 1 to review with your prescriber.
Your body processes certain psychiatric medications more slowly than most people, which means side effects may appear sooner and feel stronger than your prescriber would typically expect. Your ADHD medication response may also differ from what is typical. Decode+ identifies which specific medications are affected and what to discuss with your prescriber.
Real-World Implications
Lexapro, Celexa, and Zoloft may cause side effects faster than expected
Affects: escitalopram (Lexapro), citalopram (Celexa), sertraline (Zoloft)
If you have started Lexapro, Celexa, or Zoloft and experienced nausea, headaches, insomnia, or other side effects that came on too fast or too strong — your genetics explain why. Your body clears these specific SSRIs much more slowly, so standard doses produce significantly higher drug levels than your prescriber would expect.
Why this happens
Your CYP2C19 result is *2/*2 (Poor Metabolizer).
What clinicians sometimes consider
- CPIC recommends reduced starting doses for escitalopram and citalopram in CYP2C19 poor metabolizers
- Alternative SSRIs metabolized primarily by CYP2D6 (e.g., paroxetine, fluoxetine) may be considered
Antidepressant doses may feel slightly too strong at first
Affects: paroxetine (Paxil), fluoxetine (Prozac), venlafaxine (Effexor)
Your body clears certain antidepressants more slowly than most people. You may notice that side effects are more pronounced during the first weeks of treatment, or that doses that work well for others feel too strong for you. This is manageable — but your prescriber should know, so they can start lower and adjust.
Full analysis and clinician considerations in Decode+
Strattera (atomoxetine) may require more adjustment than typical
Affects: atomoxetine (Strattera)
Your body clears atomoxetine somewhat more slowly than average. You may be more sensitive to side effects during the first weeks of treatment and may need a longer adjustment period to find the right dose.
Full analysis and clinician considerations in Decode+
2 additional scenarios with full explanations in Decode+
Your Medication DNA — 90 Second Summary
Top Impact Areas
CYP2C19 — Poor Metabolizer
Affects: 5 psychiatric medications in this category
What this means: You break down these medications much more slowly than most people.
If you take these meds: Discuss with your prescriber about dose adjustment or alternative medications.
CYP2D6 — Intermediate Metabolizer
Affects: 5 psychiatric medications in this category
What this means: You break down these medications slightly differently than average.
If you take these meds: Mention this result when starting new medications in this category.
Gene Impact Overview
Your CYP2C19 result is *2/*2 (Poor Metabolizer).
Your CYP2D6 result is *1/*4 (Intermediate Metabolizer).
When this matters
- ●If you are starting or switching an antidepressant (SSRI/SNRI) — share these results with your prescriber so they can factor in your genetics.
- ●If you are prescribed a tricyclic antidepressant (TCA) — these medications have narrow dosing windows and your genetics may be especially relevant.
- ●If you are starting atomoxetine for ADHD — your CYP2D6 result may affect how quickly you metabolize this medication.
- ●Bring these results to your next psychiatric appointment — they stay relevant across your lifetime, even as medications change.
Based on CPIC clinical guidelines. This does not replace professional medical advice.
Scope: Decode+ evaluates CYP2D6 and CYP2C19 for psychiatric medications — the two genes with the strongest evidence. No overall “risk score” is produced; each gene stands on its own.
Based on CPIC psychiatric pharmacogenomics guidelines. Confirm all medication decisions with clinical assessment and therapeutic monitoring.
How Your DNA Affects Psychiatric Medications
Depression & Anxiety
+6 more medications checked across conditions in Decode+
Compact Decision Table
| Medication | Gene Result | Status | CPIC | Suggestion | Why |
|---|---|---|---|---|---|
| amitriptyline (Elavil) | CYP2C19 *2/*2 + CYP2D6 *1/*4 | Poor Metabolizer / Intermediate Metabolizer | Level A | Consider alternatives or adjusted dosing | Drug levels may build up |
| citalopram (Celexa) | CYP2C19 *2/*2 | Poor Metabolizer | Level A | Consider alternatives or adjusted dosing | Drug levels may build up |
| escitalopram (Lexapro) | CYP2C19 *2/*2 | Poor Metabolizer | Level A | Consider alternatives or adjusted dosing | Drug levels may build up |
| sertraline (Zoloft) | CYP2C19 *2/*2 | Poor Metabolizer | Level A | Consider alternatives or adjusted dosing | Drug levels may build up |
| vortioxetine (Trintellix) | CYP2C19 *2/*2 | Poor Metabolizer | Level A | Consider alternatives or adjusted dosing | Drug levels may build up |
Full medication-by-medication breakdown in Decode+ — 6 more medications
Detailed Findings
Result: Poor Metabolizer
Diplotype: *2/*2
Confidence: high
Metabolizer Scale
▲ You are here: Poor Metabolizer
Your CYP2C19 genotype (*2/*2) indicates you are a Poor Metabolizer with an activity score of 0.0. You may process escitalopram, citalopram, sertraline, vortioxetine, amitriptyline differently than average. CPIC guidelines recommend discussing dosing adjustments with your prescriber.
- Affected medications: escitalopram, citalopram, sertraline, vortioxetine, amitriptyline
- What to discuss: Discuss with your prescriber before starting or changing these medications.
- Evidence: CPIC Level A
References: PMID:23486447, PMID:25974703, PMID:37032427
Result: Intermediate Metabolizer
Diplotype: *1/*4
Your CYP2D6 genotype (*1/*4) indicates you are an Intermediate Metabolizer with an activity score of 1.0.
Full finding with affected medications, metabolizer scale, and CPIC recommendation in Decode+
1 additional finding with metabolizer scale, affected medications, and CPIC recommendations in Decode+
Limitations & Disclaimers
- Decode+ covers CYP2D6 and CYP2C19 only — these are the two genes with the strongest pharmacogenomic evidence for psychiatric medications. Other genes may also play a role.
- CYP2D6 gene duplications and deletions cannot be reliably detected from consumer DNA data. If CYP2D6 metabolism is a clinical concern, laboratory-grade sequencing is recommended.
- Psychiatric medication response depends on many factors beyond genetics, including diagnosis, comorbidities, other medications, lifestyle, and therapeutic monitoring. Genetics is one input among many.
- Do not stop, start, or change any psychiatric medication based solely on these results. All medication changes should be made under the supervision of a licensed prescriber.
- These results are for informational purposes only and do not constitute medical advice, diagnosis, or treatment recommendations.
- Recommendations are based on current CPIC guidelines and may be updated as new evidence emerges.
This is a sample built from fictional data for demonstration purposes. Your own results in Decode+ reflect your personal genetics.
Decode your own psychiatric medications
Upload your 23andMe or AncestryDNA raw data. See your genome overview free; unlock your psychiatric results with a one-time $59 — yours for life.
Get Started FreeFree vs Decode+
Create your account and see your genome overview free. Decode+ maps your CYP2D6 and CYP2C19 results to specific antidepressants, ADHD medications, and mood stabilizers.
Free to start
- Create your account & upload 23andMe or AncestryDNA
- Your genome overview — genes analyzed, variants found
- Export or delete your data anytime
- Which psychiatric medications are affected
- Condition-based grouping (depression, ADHD)
- CPIC dosing recommendations
Decode+
$59 one-time- Everything in free, plus:
- 18 psychiatric medications mapped to your genes
- Organized by condition (depression, ADHD, anxiety)
- Per-drug CPIC recommendations
- Carrier status, nutrition, ancestry & PRS
- The AI assistant that answers questions about your DNA
Psychiatric Pharmacogenomics from DNA You Already Have
Decode+ uses raw data from 23andMe or AncestryDNA — free to start, then a one-time $59 you own for life. Clinical psychiatric pharmacogenomic testing — such as GeneSight — typically costs several hundred to over a thousand dollars, requires a prescription and new sample, and may not be covered by insurance.
Both approaches reference CPIC clinical guidelines for CYP2D6 and CYP2C19. The difference: you already have the data.
Built on CPIC Guidelines
Every finding cites evidence from the Clinical Pharmacogenetics Implementation Consortium (CPIC) — the same guidelines used by hospitals and pharmacies worldwide. Only Level A (strong) and Level B (moderate) evidence is included.
For educational and informational purposes only. Not a substitute for clinical pharmacogenomic testing or medical advice. See our limitations page for details.
Ready to See Your Psychiatric Medication Results?
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