Sample · Decode+
See your psychiatric medication results in Decode+
See how your CYP2C19 result maps to antidepressants, ADHD medications, and mood stabilizers — and how Decode+ handles CYP2D6-dependent medications honestly. This is a real preview of what you see inside the app — personalized to your genetics.
Free to start · $59 one-time, lifetime access
What you'll see inside Decode+
Decode+ analyzes CYP2C19 and maps your psychiatric medications by condition — plus an honest flag on CYP2D6-dependent medications that can't be called from array data.
90-Second Summary
Top impact areas explained in plain language with the medications affected and when this matters.
Condition-Based Grouping
Medications organized by condition — Depression & Anxiety, ADHD, Bipolar — with action levels for each.
Decision Table
A compact reference with every affected medication, your gene result, CPIC level, and suggested consideration.
Detailed Findings
Full gene-by-gene analysis with diplotype, activity score, affected medications, and CPIC evidence level.
Your psychiatric results — full sample
Sample Data — Not Your Results
Your Psychiatric Medications
Inside Decode+ — sample preview
Based on CPIC psychiatric pharmacogenomics guidelines
Your genetics suggest 1 psychiatric medication interaction requiring attention — plus an honest flag on medications that depend on CYP2D6, which Decode+ can't call from your data.
Your body clears certain SSRIs much more slowly than most people, which means side effects may appear sooner and feel stronger than your prescriber would typically expect. Some other psychiatric medications — including certain antidepressants and atomoxetine for ADHD — depend on CYP2D6, which needs a specialized caller a consumer DNA array doesn't provide; Decode+ tells you this honestly rather than guess. Decode+ identifies which specific medications are affected and what to discuss with your prescriber.
Real-World Implications
Lexapro, Celexa, and Zoloft may cause side effects faster than expected
Affects: escitalopram (Lexapro), citalopram (Celexa), sertraline (Zoloft)
If you have started Lexapro, Celexa, or Zoloft and experienced nausea, headaches, insomnia, or other side effects that came on too fast or too strong — your genetics explain why. Your body clears these specific SSRIs much more slowly, so standard doses produce significantly higher drug levels than your prescriber would expect.
Why this happens
Your CYP2C19 result is *2/*2 (Poor Metabolizer).
What clinicians sometimes consider
- CPIC recommends reduced starting doses for escitalopram and citalopram in CYP2C19 poor metabolizers
- Alternative SSRIs metabolized primarily by CYP2D6 (e.g., paroxetine, fluoxetine) may be considered — though CYP2D6 status can't be determined from this data
Paxil, Strattera, and other CYP2D6-dependent medications can't be resolved from your array data
Affects: paroxetine (Paxil), fluoxetine (Prozac), venlafaxine (Effexor), atomoxetine (Strattera)
Paroxetine, fluoxetine, venlafaxine, and atomoxetine (Strattera) all depend on CYP2D6 for metabolism. CYP2D6 needs a specialized caller that a consumer DNA array does not provide, so Decode+ does not report a CYP2D6 result for these medications — we tell you this honestly rather than guess.
Full analysis and clinician considerations in Decode+
1 additional scenario with full explanations in Decode+
Your Medication DNA — 90 Second Summary
Top Impact Areas
CYP2C19 — Poor Metabolizer
Affects: 5 psychiatric medications in this category
What this means: You break down these medications much more slowly than most people.
If you take these meds: Discuss with your prescriber about dose adjustment or alternative medications.
CYP2D6 — Not callable from array data
Affects: 5 psychiatric medications in this category
What this means: CYP2D6 needs a specialized caller that a consumer DNA array does not provide, so Decode+ does not report a CYP2D6 result.
If you take these meds: Ask your prescriber about clinical CYP2D6 testing if this pathway is relevant to your treatment.
Gene Impact Overview
Your CYP2C19 result is *2/*2 (Poor Metabolizer).
CYP2D6 cannot be called from your array data — flagged, not guessed.
When this matters
- ●If you are starting or switching an antidepressant (SSRI/SNRI) — share these results with your prescriber so they can factor in your genetics.
- ●If you are prescribed a tricyclic antidepressant (TCA) — these medications have narrow dosing windows and your genetics may be especially relevant.
- ●If you are starting atomoxetine for ADHD — atomoxetine depends on CYP2D6, which Decode+ can't call from your array data; ask your prescriber whether specialized CYP2D6 testing is worthwhile.
- ●Bring these results to your next psychiatric appointment — they stay relevant across your lifetime, even as medications change.
Based on CPIC clinical guidelines. This does not replace professional medical advice.
Scope: Decode+ evaluates CYP2C19 for psychiatric medications — the gene it can reliably call from consumer DNA data. CYP2D6 also matters for many antidepressants, antipsychotics, and ADHD medications, but it needs a specialized caller a consumer array doesn't provide, so Decode+ flags CYP2D6-dependent medications honestly instead of guessing. No overall “risk score” is produced; each gene stands on its own.
Based on CPIC psychiatric pharmacogenomics guidelines. Confirm all medication decisions with clinical assessment and therapeutic monitoring.
How Your DNA Affects Psychiatric Medications
Depression & Anxiety
+6 more medications checked across conditions in Decode+
Compact Decision Table
| Medication | Gene Result | Status | CPIC | Suggestion | Why |
|---|---|---|---|---|---|
| amitriptyline (Elavil) | CYP2C19 *2/*2 | Poor Metabolizer (CYP2C19); CYP2D6 not callable | Level A | Consider alternatives or adjusted dosing | CYP2C19 drug levels may build up; CYP2D6 pathway can't be assessed from array data |
| citalopram (Celexa) | CYP2C19 *2/*2 | Poor Metabolizer | Level A | Consider alternatives or adjusted dosing | Drug levels may build up |
| escitalopram (Lexapro) | CYP2C19 *2/*2 | Poor Metabolizer | Level A | Consider alternatives or adjusted dosing | Drug levels may build up |
| sertraline (Zoloft) | CYP2C19 *2/*2 | Poor Metabolizer | Level A | Consider alternatives or adjusted dosing | Drug levels may build up |
| vortioxetine (Trintellix) | CYP2C19 *2/*2 | Poor Metabolizer | Level A | Consider alternatives or adjusted dosing | Drug levels may build up |
Full medication-by-medication breakdown in Decode+ — 6 more medications
Detailed Findings
Result: Poor Metabolizer
Diplotype: *2/*2
Confidence: high
Metabolizer Scale
▲ You are here: Poor Metabolizer
Your CYP2C19 genotype (*2/*2) indicates you are a Poor Metabolizer with an activity score of 0.0. You may process escitalopram, citalopram, sertraline, vortioxetine, amitriptyline differently than average. CPIC guidelines recommend discussing dosing adjustments with your prescriber.
- Affected medications: escitalopram, citalopram, sertraline, vortioxetine, amitriptyline
- What to discuss: Discuss with your prescriber before starting or changing these medications.
- Evidence: CPIC Level A
References: PMID:23486447, PMID:25974703, PMID:37032427
Result: Requires specialized testing
Diplotype: Not callable
Confidence: Not applicable — array data is insufficient to call CYP2D6
Metabolizer Scale
▲ You are here: Requires specialized testing
CYP2D6 needs a specialized caller to resolve structural and copy-number variation (gene deletions and duplications) that a consumer genotyping array cannot capture. Rather than guess, Decode+ tells you this honestly: we do not report a CYP2D6 diplotype or phenotype from your raw data. CYP2D6 affects paroxetine, atomoxetine, venlafaxine, nortriptyline, and amitriptyline.
- Affected medications: paroxetine, atomoxetine, venlafaxine, nortriptyline, amitriptyline
- What to discuss: If CYP2D6 status matters for one of these medications, ask your prescriber about laboratory-grade CYP2D6 testing.
- Evidence: CPIC Level A (for the CYP2D6 drug-gene relationship itself — not calculable from this data)
References: PharmCAT: CYP2D6 calling not recommended from VCF, CPIC guideline (CYP2D6)
Limitations & Disclaimers
- Decode+ covers CYP2C19 only — the pharmacogene it can reliably call from consumer DNA data for psychiatric medications. CYP2D6 also affects many psychiatric medications, but Decode+ does not call it — medications that depend on CYP2D6 are flagged as not-callable rather than guessed. Other genes may also play a role.
- CYP2D6 cannot be reliably called from consumer DNA data at all — not just its gene duplications and deletions. If CYP2D6 metabolism is a clinical concern, laboratory-grade testing is recommended.
- Psychiatric medication response depends on many factors beyond genetics, including diagnosis, comorbidities, other medications, lifestyle, and therapeutic monitoring. Genetics is one input among many.
- Do not stop, start, or change any psychiatric medication based solely on these results. All medication changes should be made under the supervision of a licensed prescriber.
- These results are for informational purposes only and do not constitute medical advice, diagnosis, or treatment recommendations.
- Recommendations are based on current CPIC guidelines and may be updated as new evidence emerges.
This is a sample built from fictional data for demonstration purposes. Your own results in Decode+ reflect your personal genetics.
Decode your own psychiatric medications
Upload your 23andMe or AncestryDNA raw data. See your genome overview free; unlock your psychiatric results with a one-time $59 — yours for life.
Get Started FreeFree vs Decode+
Create your account and see your genome overview free. Decode+ maps your CYP2C19 results to specific antidepressants, ADHD medications, and mood stabilizers — and honestly flags CYP2D6-dependent medications it can't call from your data.
Free to start
- Create your account & upload 23andMe or AncestryDNA
- Your genome overview — genes analyzed, variants found
- Delete your data anytime (export via support)
- Which psychiatric medications are affected
- Condition-based grouping (depression, ADHD)
- CPIC dosing recommendations
Decode+
$59 one-time- Everything in free, plus:
- 18 psychiatric medications mapped to your genes
- Organized by condition (depression, ADHD, anxiety)
- Per-drug CPIC recommendations
- Carrier status, nutrition, ancestry & PRS
- The AI assistant that answers questions about your DNA
Psychiatric Pharmacogenomics from DNA You Already Have
Decode+ uses raw data from 23andMe or AncestryDNA — free to start, then a one-time $59 you own for life. Clinical psychiatric pharmacogenomic testing — such as GeneSight — typically costs several hundred to over a thousand dollars, requires a prescription and new sample, and may not be covered by insurance.
Both approaches reference CPIC clinical guidelines for CYP2C19 and CYP2D6. The difference: you already have the data — though CYP2D6 still requires specialized testing beyond what a consumer array can provide.
Built on CPIC Guidelines
Every finding cites evidence from the Clinical Pharmacogenetics Implementation Consortium (CPIC) — the same guidelines used by hospitals and pharmacies worldwide. Only Level A (strong) and Level B (moderate) evidence is included.
For educational and informational purposes only. Not a substitute for clinical pharmacogenomic testing or medical advice. See our limitations page for details.
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