Nutrition & Methylation Report

What This Report Does

The Nutrition & Methylation Report analyzes your genetic variants in MTHFR, COMT, FUT2, VDR, BCMO1, TCN2, and other nutrient-metabolism genes. It maps your genotypes to the nutrigenomics research literature to identify areas where your genetics may affect how you process specific nutrients.

Your report provides a priority dashboard ranking your top nutrient areas, genotype-specific context for each finding, and a tiered action plan organized by evidence strength — starting with food-first strategies before considering supplementation.

Genes Analyzed

The report focuses on genes with the strongest evidence for clinically relevant nutrient-metabolism effects:

• MTHFR — Folate metabolism and methylation. The C677T variant (rs1801133) can reduce enzyme activity by up to 70%, affecting folate conversion and homocysteine regulation.
• FUT2 — Vitamin B12 absorption. Non-secretor variants affect gut B12 uptake and are associated with lower circulating B12 levels.
• VDR — Vitamin D metabolism. Variants affect how your body responds to and utilizes vitamin D.
• COMT — Catechol-O-methyltransferase activity. The Val158Met variant affects how your body processes catechol compounds and may influence methylation demand.
• TCN2 — Vitamin B12 transport. Variants can affect how efficiently B12 is delivered to cells, complementing FUT2 absorption data.
• BCMO1 — Vitamin A conversion. Variants reduce the efficiency of converting beta-carotene from plant foods into usable retinol.

For a deeper introduction to these genes and how they interact with your diet, see our guide on what nutrigenomics is.

What You'll See in Your Report

• Priority dashboard: Your top nutrient-metabolism findings ranked by clinical relevance and evidence strength.
• Genotype-specific context: For each gene, your genotype, what it means, and how it compares to population frequencies.
• Tiered action plan: Practical steps organized by evidence level — food-first strategies, nutrient forms to consider, and when to discuss with your healthcare provider.
• Evidence ratings: Each finding includes the strength of supporting evidence so you can distinguish well-established associations from emerging research.
• MTHFR deep-dive: Detailed analysis of both MTHFR variants (C677T and A1298C), including compound heterozygosity context. See our MTHFR C677T guide for a preview of this analysis.

Who This Report Is For

• People interested in understanding how their genetics may affect nutrient metabolism — folate, B12, vitamin D, omega-3 fatty acids, and vitamin A.
• People who have learned they carry MTHFR variants and want clear, evidence-based context rather than hype or fear-based information.
• Anyone with 23andMe, AncestryDNA, or other consumer DNA data who wants to extract nutrigenomic insights from raw data they already have.
• People working with a healthcare provider or dietitian who want genetic context to complement lab work and dietary assessment.

What This Report Does NOT Do

• This report does not diagnose nutritional deficiencies, diseases, or medical conditions.
• It does not tell you exactly what to eat or generate personalized meal plans.
• It does not replace blood work. Genetics shows predisposition; lab tests show current nutrient levels.
• It does not recommend specific supplements or dosages. Supplementation decisions should involve your healthcare provider.
• This is not medical advice. All dietary and supplement decisions should be made with your healthcare provider. See our full limitations page.

How It Works

1. Upload your DNA data from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA.
2. Your raw data is analyzed to extract nutrient-metabolism variants and assign genotypes for MTHFR, COMT, FUT2, VDR, BCMO1, TCN2, and other genes.
3. Results are mapped to the research literature for each nutrient pathway, identifying areas where your genetics may affect nutrient processing.
4. Your report is generated with a priority dashboard, genotype-specific context, and a tiered action plan.

For details on the analysis pipeline, see our methodology page or read about what nutrigenomics is.

Consumer DNA Data Coverage

Consumer genotyping arrays from 23andMe and AncestryDNA reliably cover the key SNPs for the nutrigenomic genes analyzed in this report. Your raw data likely contains:

• MTHFR C677T (rs1801133) and A1298C (rs1801131) — the two most clinically studied MTHFR variants
• FUT2 secretor status variants relevant to B12 absorption
• VDR variants associated with vitamin D metabolism
• COMT Val158Met variant affecting catechol metabolism
• TCN2 variants affecting vitamin B12 cellular transport
• BCMO1 variants affecting beta-carotene to vitamin A conversion

Unlike pharmacogenomic genes such as CYP2D6 (where structural variants can be missed by consumer arrays), the nutrigenomic variants in this report are well-covered by standard genotyping arrays. See what to do with your 23andMe raw data for a full walkthrough.

Frequently Asked Questions

Learn More

• Methylation Testing: What It Can and Can't Tell You — Blood biomarkers vs genetic testing for methylation pathways.
• What Is Nutrigenomics? — An introduction to how your genes affect nutrient metabolism.
• MTHFR C677T: What It Means and What to Do — A practical guide to the most studied nutrigenomic variant.
• What To Do With Your 23andMe Raw Data — How to extract health insights from DNA data you already have.
• What Is Pharmacogenomics? — The sister field to nutrigenomics, focused on medication metabolism.